I am delighted to see the launch of this Special Issue, “Advances in Asymmetric Catalysis: From Mechanisms to Applications”, edited by Guest Editors Mario Waser and Shengcai Zheng. Having had the opportunity to propose the theme of this Special Issue, I am especially pleased to see it come to fruition. The synthesis of chiral compounds in high optical purity is critically important in medicinal and agrochemical chemistry. K. Barry Sharpless, Ryoji Noyori, and William S. Knowles were awarded the 2001 Nobel Prize in Chemistry for their pioneering contributions to asymmetric oxidation and asymmetric reduction catalysis. These transformations have been primarily achieved using transition-metal catalysts based on elements such as titanium, ruthenium, and rhodium. Subsequently, a wide variety of asymmetric carbon–carbon bond-forming reactions employing chiral Lewis acid and chiral Lewis base catalysts were developed, leading to remarkable advances in asymmetric catalysis.